Fallout 76 Guide to Mutations

Mutations in Fallout 76 are one of the most vital parts to completing off some of the best builds in the game. You’re able to acquire a BUNCH of different mutations that all do different things, some more useful to your build than others. Look over all the options, and figure out which ones best benefit your play style in Fallout 76!

The MOST Important Part of Mutations

Before you even TRY to get Mutations, you need to make sure you have 2 very specific LUCK Perk Cards, and those would be:

  • Class Freak
  • Starched Genes

Starched Genes is 100% a must with Mutations and is the most important out of those two Perk Cards. Make sure you MAX it out (Only takes 2 SPECIAL Points) as this will prevent you from accidentally healing away your mutations, which is VERY easy to do. 

Class Freak, on the other hand, will lessen the negative effects of your Mutations, as each and every mutations has both GOOD effects and BAD effects, and trust me, without Class Freak you’ll be hit pretty hard by the negatives. Not everyone goes all 3 on Class Freak, but if you’re going to be a Mutation build, you might as well.


How to Get Mutations

Lets just get RIGHT to the point, cause you want (need) mutations, and you need (want) them now.

Mutations can be acquired through 2 different ways, either standing in incredibly radiated areas for prolonged periods of time or simply drinking the mutation serum. Obviously one of these ways is far more efficient. At least on time, but on caps? Depends where you get them. Lets talk about the ups and downs to each tactic.

Mutations from Radiation

Fallout 76 Guide to Mutations

This is the tactic that requires you to simply stand in areas that are highly irradiated. This could be standing in toxic water, next to toxic waste barrels, or even just fighting super radiated enemies.. and LETTING them hit you. 

The upside to getting mutations this way, is that it’s easy and free. You can literally just go around getting smacked by ghouls and get some mutations that way. It doesn’t require you to spend a single cap or go hunting around for mutations, you just get it.

Now the DOWNSIDES of this tactic is that you don’t necessarily get what you want. That means that you’ll be swapping your “Starched Genes” Park Card on and off to “Heal” away the wrong mutation. This ALSO means that you might end up with a bunch of mutations you DON’T want, and if you try to heal away the ones you don’t like, well, you might just heal away the ones you DO want. 

This way is quite messy, but if you truly don’t care about what mutations you get and you just want them for free, you might as well.

Mutations from Serum

This is the best way to get Mutations, because you get EXACTLY what you want, and typically for around 500-1000 caps. You can actually BUY the Mutation recipes from the Enclave in the Medical bay, and then CRAFT them yourself, meaning you can them distribute them to other players who want those specific Mutations. The Serum RECIPE, however, is incredibly expensive. You can definitely turn a profit if you buy and sell a popular mutation serum, but for the most part it’s smarter to just buy the serums from player vendors.

Mutation Serums are named EXACTLY which mutation you’ll get from drinking it, so you never have to guess what you might get. This way of getting Mutations is definitely the cleanest, and doesn’t involve any “healing” away of unwanted mutations, or HOPING you’ll get the one you want.

Types of Mutations

Fallout 76 Guide to Mutations

There are a total of 19 different types of Mutations to get, each offering it’s own benefits. Remember, not ALL mutations are worth having on your build, as some will only negatively impact what you’re running. Make sure you read through each one and decide which best will help you. Also, some are just fun to have.




Adrenal Reaction

More Weapon Damage at Lower Health

Max Health -50

Bird Bones

Agility +4
Falling from Heights is Gradually Slowed

Strength -4


Won’t get Disease from eating Meat.
2 Times the Bonuses from Eating Meat

Eating Fruits and Vegetables with NOT Satisfy Hunger


Turn Invisible if not wearing armor and standing still

Cannot be wearing armor or attacking for the effect to work

Eagle Eyes

Critical Damage Increased by +25%.
Perception +4

Strength -4

Egg head

Intelligence +6

Strength -3
Endurance -3

Electrically Charged

Have a chance to deal shock damage to Melee Attackers

Shock Damage deals damage to player


Teamates will take 25% Less damage

Player takes 33% More Damage


Energy Resistance Increased by +100

Energy DAMAGE Decreased by -50%

Healing factor

Health Regeneration while not in Combat increased by +300%

Chem Effects are decreased by -55%


Vegetables give 2 times the benefit and won’t cause diseases

Meat won’t satisfy hunger

Herd Mentality

All SPECIAL Stats are increased by +2 when in a Team

SPECIAL Stats are decreased by -2 while NOT in a Team


Carry Weight increased by +20
Jump Height Increased

Intelligence -4

Plague Walker

Creates a Poison Aura that scales with your diseases

Must be Diseased for this to work

Scaly Skin

Damage and Energy Resistance increased by +50

Action Point decreased by -50

Speed Demon

Movement and Reload Speed increased by +20%

Hunger and Thirst drains 50% Faster while moving


Unarmed Punching attacks dealing 25% more damage + Bleed Damage

Agility -4

Twisted Muscles

Melee Damage increased by +25%, higher chance to cripple limbs

Gun Accuracy Decreased by -50%

Unstable Isotope

Slight chance to release a Radiation Burst when struck by a Melee attack

Deals minor Damage to the Player during the Radiation Burst

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